Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
نویسندگان
چکیده
منابع مشابه
Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease.
IMPORTANCE Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD. We investiga...
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BACKGROUND The significance of Lewy bodies detected at autopsy in the brains of clinically normal individuals is uncertain but may represent preclinical Parkinson disease (PD). OBJECTIVE To determine whether diminished striatal dopaminergic innervation and nigral cell loss are present in incidental Lewy body disease (iLBD), as one might expect if it is a forerunner of PD. DESIGN Case-contro...
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ژورنال
عنوان ژورنال: JAMA Neurology
سال: 2015
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2014.2704